Theme: Stressors to ResponsesInvestigating Mechanisms linking ENvironmental Stressors to adverse Health Responses
The mission of this theme is to establish multidisciplinary research groups focused on detecting specific environmental stressors, elucidating the mechanism by which these stressors impact biological systems, and identify diseases and adverse biological responses associated with environmental stressor exposure. Though this may seem a broad area of research, particular focus will be placed on identifying the commonalities among stressors, models, and diseases. As such, this theme will serve as an integrating node for groups working across the exposure-to-disease spectrum. It will present investigators with opportunity to discuss and exchange approaches, techniques, and experimental designs that have been successful in demonstrating how stressors impact biological systems, as well as identify experimental intersections and explore technologies available in the Facility Cores. Intellectual exchanges among researchers participating in this theme will ideally lead to new collaborations and higher impact outcomes.
- Stressors being investigated include: toxins such as arsenic, lead, chromium, and aflatoxin; toxicants such as halogenated aromatics, polycyclic aromatic hydrocarbons, endocrine disruptors, dioxins, and trichloroethylene; air pollutants; physical activity; behavioral stress; and the microbiota.
- Some research groups have begun to investigate the impact of complex natural and chemical mixtures such as in the diet, air pollution, pesticides, and petroleum mixtures contaminating the Galveston Bay and Houston Ship Channel.
- Model systems used: cellular, organoid, rodent, and human clinical systems.
- Biological and disease outcomes: reprotoxicity, nephrotoxicity, hepatoxicity, cardio and pulmonary toxicity, immunotoxicity, neurological disease, and general biological responses.
Research THEME LEADER
Dr. Joe Arosh is a professor in A&M's Department of Veterinary Integrative Biosciences. His research program investigates the mechanims by which prenatal chromium exposure contributes to reduced reproductive health.